Who was studied, and how
Four numbers in the abstract
Where each one falls
Only readable comparisons vote
Where it lands on the map
What it changes
Among 21 other studies
12,705people with hypertension, in this paper
The trial randomly assignedassigned by chance
combined-therapy group (rosuvastatin and the two antihypertensive agents)
dual-placebo group
Lowered first coprimary outcome−29%
Lowered second coprimary outcome−28%
Reported lower the LDL cholesterol level, no range given−33.7
randomisedthe abstract, start to end
… in the LDL cholesterol level was 33.7 mg per deciliter (0.87 mmol per liter) greater in the combined-therapy group than in the dual-placebo group, and the decrease in systolic blood pressure was 6.2 mm Hg greater with combined …
… in the dual-placebo group (hazard ratio, 0.71; 95% confidence interval [CI], …
… (5.9%), respectively (hazard ratio, 0.72; 95% CI, 0.57 to 0.89; …
← favours treatmentfavours comparator →
could be chanceNo interval given · direction only, strength unknown
Decrease in the LDL cholesterol levelcombined-therapy group (rosuvastatin and the two antihypertensive agents) vs dual-placebo group
−33.7
Decrease in systolic blood pressurecombined-therapy group (rosuvastatin and the two antihypertensive agents) vs dual-placebo group
−6.20
First coprimary outcome (composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke)combined-therapy group (rosuvastatin and the two antihypertensive agents) vs dual-placebo group
HR 0.710.56–0.90
Second coprimary outcome (first coprimary outcome additionally included heart failure, cardiac arrest, or revascularization)combined-therapy group (rosuvastatin and the two antihypertensive agents) vs dual-placebo group
HR 0.720.57–0.89
StatinsAntihypertensivesLipidsBlood pressureCardiovascular events
Antihypertensives × cardiovascular eventshelps?one trial
unlikelylikely
0.50only evidence
Statins × cardiovascular eventshelps?replicated
unlikelylikely
0.860.85 without it
← favours treatmentfavours comparator →
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