Statins × adverse events & safety

SynthesisDrugs & aging2020

The Safety and Tolerability of Statin Therapy in Primary Prevention in Older Adults: A Systematic Review and Meta-analysis.

Zhen Zhou et al.PubMed ↗Publisher ↗

  • Statinsno clear effectNo clear effect on muscle-related symptoms.Nothing cleared the noise.

What the trial testedas reported · 18,192 people · 2020

Range includes no effect

No clear effect on muscle-related symptoms

+1%−10% to +12%

statins vs placebo, in older adults without overt CVD (aged ≥65 years)

Smaller than almost all for adverse events & safety

As reported

RR 1.01, 95% CI 0.90–1.12

Who was studied, and how

18,192people with cardiovascular disease, aged 65+, in this paper

Among older adults without overt CVD (aged ≥65 years), the trial randomly assignedassigned by chance

statins
placebo

No clear effect on muscle-related symptoms+1%

randomised

the abstract, start to end

the risks of muscle-related symptoms (RR 1.01; 95% CI 0.90-1.12), total

← favours treatmentfavours comparator →
could be chance
Muscle-related symptomsstatins vs placebo, in older adults without overt CVD (aged ≥65 years)
RR 1.010.90–1.12
StatinsAdverse events & safety

Statins × adverse events & safetyharms?mixed

unlikelylikely
0.16not counted
← favours comparatorfavours treatment →
more certainless certain
1 / 6

17 papers cite it

2020
2021
2022
2023
2024
2025
2026
this paperpooled ittrialcites it
Full record →Abstract, authors, funding and every citing paper · PMID 31919804