Evidence mapPaperPMID 27614854Full record

Trial reportThe American journal of cardiology2016

Metabolic Markers to Predict Incident Diabetes Mellitus in Statin-Treated Patients (from the Treating to New Targets and the Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trials).

Payal Kohli, Joshua W Knowles, Ashish Sarraju, David D Waters, Gerald Reaven

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The American journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT02437084. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02437084 phase4completed

Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling

Ran2015Enrolled115Registered outcomes6Posted comparisons6ConditionsHyperlipidemia, Insulin Resistance, Type 2 DiabetesArmsAtorvastatin
Open the trial in the graph
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Statins Are Associated With Increased Insulin Resistance and Secretion.Arteriosclerosis, thrombosis, and vascular biology · 2021 · on this map
    Trial
  2. Statin Induced New-onset Diabetes Mellitus - A Narrative Review.Journal of community hospital internal medicine perspectives · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. 2022 Saudi Guidelines for the Management of Dyslipidemia.Heart views : the official journal of the Gulf Heart Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Payal KohliDivision of Cardiology, Department of Medicine, Kaiser Permanente, Denver, Colorado; Division of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California.
Joshua W KnowlesDivision of Cardiovascular Medicine and Cardiovascular Institute, Department of Medicine, Stanford University, Stanford, California. Electronic address: knowlej@stanford.edu.
Ashish SarrajuDivision of Cardiovascular Medicine and Cardiovascular Institute, Department of Medicine, Stanford University, Stanford, California.
David D WatersDivision of Cardiology, Department of Medicine, University of California, San Francisco, San Francisco, California.
Gerald ReavenDivision of Cardiovascular Medicine and Cardiovascular Institute, Department of Medicine, Stanford University, Stanford, California.
Cardiovascular Institute of the South · USKaiser Permanente · USUniversity of California, San Francisco · US

Funding

Doris Duke Charitable Foundation 2016097
6 · The paper itself

Abstract

The goal of this analysis was to evaluate the ability of insulin resistance, identified by the presence of prediabetes mellitus (PreDM) combined with either an elevated triglyceride (TG >1.7 mmol/l) or body mass index (BMI ≥27.0 kg/m

Indexed as

AtorvastatinBiomarkersBlood GlucoseBody Mass IndexDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceInsulin ResistanceIschemic Attack, TransientLipidsMaleMiddle AgedPrediabetic StateAtorvastatinBiomarkersBlood GlucoseHydroxymethylglutaryl-CoA Reductase InhibitorsLipids

Identifiers

PMID27614854
PMCPMC6686184
OpenAlexW2517043028

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.