DPP-4 inhibitors × glycemic control

TrialDiabetes, obesity & metabolism2017

Efficacy and safety of initial combination therapy with gemigliptin and metformin compared with monotherapy with either drug in patients with type 2 diabetes: A double-blind randomized controlled trial (INICOM study).

Soo Lim et al.PubMed ↗Full text ↗Publisher ↗

  • Gemigliptin 50 mg qd + metformin 1000 to 2000 mg qdno clear effectLower HbA1c level, no range given.No ranges given.
  • Gemigliptin 50 mg qdno clear effectLower HbA1c level, no range given.No ranges given.
  • Metformin 1000 to 2000 mg qdno clear effectLower HbA1c level, no range given.No ranges given.

What the trial testedas reported · 2017

No range given

Reported lower HbA1c level, no range given

−2.06percentage points

gemigliptin 50 mg qd + metformin 1000 to 2000 mg qd vs baseline

As reported

difference −2.06 %, no interval

No range given

Reported lower HbA1c level, no range given

−1.24percentage points

gemigliptin 50 mg qd vs baseline

As reported

difference −1.24 %, no interval

No range given

Reported lower HbA1c level, no range given

−1.47percentage points

metformin 1000 to 2000 mg qd vs baseline

As reported

difference −1.47 %, no interval

Who was studied, and how

people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

gemigliptin 50 mg qd + metformin 1000 to 2000 mg qd
baseline

Reported lower HbA1c level, no range given−2.06

randomised

The trial randomly assignedassigned by chance

gemigliptin 50 mg qd
baseline

Reported lower HbA1c level, no range given−1.24

randomised

the abstract, start to end

level from baseline to week 24 were -2.06%, -1.24% and -1.47% in the combination,

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
HbA1c levelgemigliptin 50 mg qd + metformin 1000 to 2000 mg qd vs baseline
−2.06
HbA1c levelgemigliptin 50 mg qd vs baseline
−1.24
HbA1c levelmetformin 1000 to 2000 mg qd vs baseline
−1.47
MetforminDPP-4 inhibitorsGlycemic control
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Full record →Abstract, authors, funding and every citing paper · PMID 27619558