DPP-4 inhibitors × glycemic control

TrialDiabetes, obesity & metabolism2017

Efficacy and safety of canagliflozin as add-on therapy to teneligliptin in Japanese patients with type 2 diabetes mellitus: Results of a 24-week, randomized, double-blind, placebo-controlled trial.

Takashi Kadowaki et al.PubMed ↗Full text ↗Publisher ↗

  • Teneligliptin 20 mg plus canagliflozin 100 mg (T+C)looks good hereLower HbA1c change from baseline to week 24, no range given.No ranges given.

What the trial testedas reported · 138 people · 2017

No range given

Reported lower HbA1c change from baseline to week 24, no range given

−0.88percentage points

teneligliptin 20 mg plus canagliflozin 100 mg (T+C) vs teneligliptin 20 mg plus placebo (T+P)

As reported

difference −0.88 %, no interval

Who was studied, and how

138people with obesity, in this paper

The trial randomly assignedassigned by chance

teneligliptin 20 mg plus canagliflozin 100 mg (T+C)
teneligliptin 20 mg plus placebo (T+P)

Reported lower HbA1c change from baseline to week 24, no range given−0.88

randomised

the abstract, start to end

change from baseline to week 24 was -0.88% (least-squares mean,

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
HbA1c change from baseline to week 24teneligliptin 20 mg plus canagliflozin 100 mg (T+C) vs teneligliptin 20 mg plus placebo (T+P)
−0.88
SGLT2 inhibitorsDPP-4 inhibitorsGlycemic control

DPP-4 inhibitors × glycemic controlhelps?replicated

unlikelylikely
0.820.82 without it

SGLT2 inhibitors × glycemic controlhelps?replicated

unlikelylikely
0.920.92 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 28177187