Who was studied, and how
Five numbers in the abstract
Where each one falls
Only readable comparisons vote
Where it lands on the map
What it changes
Among 23 other studies
143people with type 2 diabetes, in this paper
The trial randomly assignedassigned by chance
ipragliflozin 50 mg/day as add-on therapy to metformin and sitagliptin
placebo as add-on therapy to metformin and sitagliptin
Probably lowered long-term blood sugar−0.83
Reported lower fasting blood sugar, no range given−1.64
Reported lower fasting serum insulin, no range given−1.50
randomisedthe abstract, start to end
… ipragliflozin (adjusted mean difference -0.83% [95% CI -1.07 to -0.59]; P < …
… ipragliflozin (adjusted mean difference -1.64 mmol/L, -1.50 μU/mL, -1.72 kg, and -0.99, respectively; P < .05 for …
← favours treatmentfavours comparator →
could be chanceNo interval given · direction only, strength unknown
Change in glycated haemoglobin (HbA1c) from baseline to end of treatment (EOT)ipragliflozin 50 mg/day as add-on therapy to metformin and sitagliptin vs placebo as add-on therapy to metformin and sitagliptin
−0.83−1.07 to −0.59
Fasting plasma glucoseipragliflozin 50 mg/day as add-on therapy to metformin and sitagliptin vs placebo as add-on therapy to metformin and sitagliptin
−1.64
Fasting serum insulinipragliflozin 50 mg/day as add-on therapy to metformin and sitagliptin vs placebo as add-on therapy to metformin and sitagliptin
−1.50
Body weightipragliflozin 50 mg/day as add-on therapy to metformin and sitagliptin vs placebo as add-on therapy to metformin and sitagliptin
−1.72
Homeostatic model assessment of insulin resistanceipragliflozin 50 mg/day as add-on therapy to metformin and sitagliptin vs placebo as add-on therapy to metformin and sitagliptin
−0.99
MetforminSGLT2 inhibitorsDPP-4 inhibitorsGlycemic controlBody weight & compositionAdverse events & safety
DPP-4 inhibitors × glycemic controlhelps?replicated
unlikelylikely
0.820.82 without it
Metformin × glycemic controlhelps?replicated
unlikelylikely
0.840.84 without it
SGLT2 inhibitors × glycemic controlhelps?replicated
unlikelylikely
0.920.92 without it
← favours treatmentfavours comparator →
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