GLP-1 receptor agonists × cardiovascular events

TrialThe New England journal of medicine2019

Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.

Mansoor Husain et al.PubMed ↗Publisher ↗

What the trial testedrandomised · 3,183 people · 2019

Randomised comparison

Reduced cardiovascular events

−51%−73% to −8%

1 in 100 instead of 2

Bigger than 9 in 10 for cardiovascular events

As reported

HR 0.49, 95% CI 0.27–0.92

Randomised comparison

Reduced deaths

−49%−69% to −16%

1 in 100 instead of 3

Bigger than 9 in 10 for all-cause mortality

As reported

HR 0.51, 95% CI 0.31–0.84 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on cardiovascular events

−21%−43% to +11%

4 in 100 instead of 5

Bigger than 5 in 10 for cardiovascular events

As reported

HR 0.79, 95% CI 0.57–1.11

Range includes no effect

No clear effect on cardiovascular events

+18%−27% to +90%

About 2 in 100 either way

Bigger than 3 in 10 for cardiovascular events

As reported

HR 1.18, 95% CI 0.73–1.90

+1 more in the walkthrough ↓

Five numbers in the abstract

the abstract, start to end

in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI],

in the placebo group (hazard ratio, 0.49; 95% CI, 0.27 to 0.92); nonfatal myocardial infarction, 37 of 1591 patients (2.3%) and 31 of 1592 (1.9%), respectively (hazard ratio, 1.18; 95% CI, 0.73 to 1.90); and nonfatal stroke, 12 of 1591 patients (0.8%) and 16 of 1592 (1.0%), respectively (hazard ratio, 0.74; 95% CI, 0.35 to 1.57).

in the placebo group (hazard ratio, 0.51; 95% CI, 0.31 to 0.84).

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
HR 0.790.57–1.11
Cardiovascular events
HR 0.490.27–0.92
Cardiovascular events
HR 1.180.73–1.90
Cardiovascular events
HR 0.740.35–1.57
All-cause mortality
HR 0.510.31–0.84
GLP-1 receptor agonistsCardiovascular eventsAll-cause mortality

GLP-1 receptor agonists × cardiovascular eventshelps?mixed

unlikelylikely
0.500.78 without it

GLP-1 receptor agonists × all-cause mortalityhelps?replicated

unlikelylikely
0.881.00 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 31185157