Evidence map›Paper›PMID 9094069›Full record

ArticleMagnetic resonance in medicine1997

In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy.

C Boesch, J Slotboom, H Hoppeler, R Kreis

2 registry-linked trialsAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Magnetic resonance in medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 122 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07065383 narecruitingstarted 2025, after this paper: background citation

Intramyocellular Lipid Compartments After Glucagon-like Peptide 1 Receptor Agonist Therapy in Type 2 Diabetes - Rebalancing the Fat Content of the Heart and Muscles

Ran2025Enrolled60Registered outcomes2Posted comparisons0ConditionsDiabetes Mellitus Type 2ArmsSemaglutide administration plus dietary counselling and physical activity encouragement, Semaglutide plus a personalised and supervised program of resistance and endurance training
PMID 28266779PMID 33567185PMID 37952131PMID 27633186PMID 22547801PMID 35296869PMID 34675928PMID 3292505PMID 30586731PMID 30131397PMID 29203776PMID 27553599other papers from this trial
Open the trial in the graph
NCT02360046 naterminatednot on this mapstarted 2015, after this paper: background citation

The Influence of Different Hydrocortisone Replacement Doses on the Partitioning and Flexibility of Ectopic Lipids (Intrahepatocellular IHCL and Intramyocellular IMCL) in Patients With Corticotropic Hypopituitarism, a Randomised Placebo-controlled Double-blind Trial

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2015 to 2016Enrolled30ConditionsHypopituitarism, Hydrocortisone, Lipids, Fatty Acids, NonesterifiedArmsHydrocortisone, Placebo
3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  7. Effect of insulin versus triple oral therapy on the progression of hepatic steatosis in type 2 diabetes.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2012
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  18. Triglycerides, Glucose Metabolism, and Type 2 Diabetes.International journal of molecular sciences · 2025
    Review
  19. Advances inFrontiers in endocrinology · 2025
    Review
  20. Optimization ofMagnetic resonance in medicine · 2025
    Article

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

C BoeschDepartment of MR-Spectroscopy and Methodology, University of Bern, Switzerland.
J Slotboom
H Hoppeler
R Kreis

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intra-myocellular lipids (IMCL) are stored in droplets in the cytoplasm of muscle cells and are an energy storage form readily accessed during long-term exercise. 1H-MR spectroscopy methods are presented for noninvasive determination of IMCL in human muscle. This is based on (a) the separation of two resonances in the lipid-CH2-region, with the one assigned to IMCL being independent of muscle orientation relative to the magnetic field and (b) the fact that IMCL resonances scale along with signal amplitudes of metabolites in the muscle cell (e.g., creatine) when voxel size is increased, while lipid signals of bulk fat show a disproportionate growth. Inter-individual and intra-individual reproducibility studies indicate that the error of the method is about 6% and that IMCL levels differ significantly between identical muscles in different subjects, as well as intra-individually when measured at 1 week intervals. IMCL determinations in a single subject before and after strenuous exercise indicate that lipid stores recover with a t1/2 of about 1 day.

Indexed as

AdultExerciseFemaleHumansLegLipidsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMuscle, SkeletalProtonsReproducibility of ResultsLipidsProtons

Identifiers

PMID9094069

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.