Statins × all-cause mortality

SynthesisThe Cochrane database of systematic reviews2013

Statins for the primary prevention of cardiovascular disease.

Fiona Taylor et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 56,934 people · 2013

Randomised comparison

Reduced deaths

−14%−21% to −6%

Bigger than 4 in 10 for all-cause mortality

As reported

OR 0.86, 95% CI 0.79–0.94 · the paper's word: All-cause mortality

Randomised comparison

Reduced deaths

−25%−30% to −19%

Bigger than 7 in 10 for all-cause mortality

As reported

RR 0.75, 95% CI 0.70–0.81 · the paper's word: All-cause mortality

Randomised comparison

Reduced deaths

−27%−33% to −20%

Bigger than 8 in 10 for all-cause mortality

As reported

RR 0.73, 95% CI 0.67–0.80 · the paper's word: All-cause mortality

Randomised comparison

Reduced deaths

−22%−32% to −11%

Bigger than 7 in 10 for all-cause mortality

As reported

RR 0.78, 95% CI 0.68–0.89 · the paper's word: All-cause mortality

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Five numbers in the abstract

the abstract, start to end

mortality was reduced by statins (OR 0.86, 95% CI 0.79 to 0.94); as was combined fatal and non-fatal CVD RR 0.75 (95% CI 0.70 to 0.81), combined fatal and non-fatal CHD events RR 0.73 (95% CI 0.67 to 0.80) and combined fatal and non-fatal stroke (RR 0.78, 95% CI 0.68 to 0.89).

Reduction of revascularisation rates (RR 0.62, 95% CI 0.54 to 0.72) was also

← favours treatmentfavours comparator →
could be chance
All-cause mortality
OR 0.860.79–0.94
All-cause mortality
RR 0.750.70–0.81
All-cause mortality
RR 0.730.67–0.80
All-cause mortality
RR 0.780.68–0.89
Cardiovascular events
RR 0.620.54–0.72
StatinsCardiac procedures & devicesCardiovascular eventsAll-cause mortality

Statins × all-cause mortalityhelps?mixed

unlikelylikely
0.50not counted

Cardiac procedures & devices × cardiovascular eventshelps?mixed

unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
more certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 23440795