GLP-1 receptor agonists × blood pressure

TrialDiabetes care2009

Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD).

Bernard Zinman et al.PubMed ↗Full text ↗Publisher ↗

  • Liraglutide (1.2 or 1.8 mg)no clear effectLower A1C values, no range given.No ranges given.
  • Liraglutide 1.2 mgno clear effectLower systolic blood pressure, no range given.No ranges given.

What the trial testedas reported · 533 people · 2009

No range given

Reported lower A1C values, no range given

−1.00

liraglutide (1.2 or 1.8 mg) vs placebo

As reported

difference −1.00, no interval

No range given

Reported lower systolic blood pressure, no range given

−5.60

liraglutide 1.2 mg vs placebo

As reported

difference −5.60, no interval

Who was studied, and how

576people in the Effect on Glycemic Control of Liraglutide in Combination With Rosiglitazone Plus Metformin Versus Rosiglitazone Plus Metformin in Subjects With Type 2 Diabetes trial, from 2006
533of them with hypertension, in this paper

The trial randomly assignedassigned by chance

liraglutide (1.2 or 1.8 mg)
placebo

Reported lower A1C values, no range given−1.00

randomised

The trial randomly assignedassigned by chance

liraglutide 1.2 mg
placebo

Reported lower systolic blood pressure, no range given−5.60

randomised

the abstract, start to end

Mean A1C values decreased significantly

Systolic blood pressure decreased by 6.7, 5.6, and 1.1 mmHg with 1.2 and 1.8

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
A1C valuesliraglutide (1.2 or 1.8 mg) vs placebo
−1.00
Systolic blood pressureliraglutide 1.2 mg vs placebo
−5.60
GLP-1 receptor agonistsGlycemic controlBlood pressure
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Full record →Abstract, authors, funding and every citing paper · PMID 19289857