Insulin × body weight & composition

TrialDiabetologia2009

Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial.

D Russell-Jones et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 581 people · 2009

No range given

Reported higher body weight & composition, no range given

+0.69

As reported

difference 0.69, no interval

No range given

Reported higher body weight & composition, no range given

+2.86

As reported

difference 2.86, no interval

No range given

Reported lower blood pressure, no range given

−2.20

As reported

difference −2.2, no interval

Three numbers in the abstract

the abstract, start to end

difference -1.39 kg, 95% CI 2.10, 0.69; p = 0.0001), and vs glargine (treatment difference -3.43 kg, 95% CI 4.00, 2.86; p < 0.0001).

mmHg; -4.5 mmHg difference, 95% CI 6.8, -2.2; p = 0.0001) but not vs placebo

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Body weight & composition
0.69
Body weight & composition
2.86
Blood pressure
−2.2
GLP-1 receptor agonistsInsulinBody weight & compositionBlood pressure

Insulin × body weight & compositionhelps?mixed

unlikelylikely
0.000.00 without it

GLP-1 receptor agonists × blood pressurehelps?mixed

unlikelylikely
0.500.50 without it

Insulin × blood pressurehelps?one trial

unlikelylikely
0.35only evidence
← favours treatmentfavours comparator →
this papermore certainless certain
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Full record →Abstract, authors, funding and every citing paper · PMID 19688338