Evidence map›Paper›PMID 29703793›Full record

Trial reportEuropean journal of endocrinology2018

Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.

Vesna Salamun, Mojca Jensterle, Andrej Janez, Eda Vrtacnik Bokal

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 98 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 17 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05952882 phase3unknown statusstarted 2023, after this paper: background citation

Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility

Ran2023Enrolled188Registered outcomes60Posted comparisons0ConditionsInfertility, Female, Obesity, Polycystic Ovary SyndromeArmsLiraglutide + metformin, Metformin
PMID 18364705PMID 28681988PMID 19056992PMID 31229399PMID 19841045PMID 31733195PMID 24362411PMID 14688154PMID 17980364PMID 18068166PMID 22767467PMID 24151290other papers from this trial
Open the trial in the graph
NCT07242534 phase4recruitingstarted 2026, after this paper: background citation

Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization. A Randomized Controlled Trial

Ran2026Enrolled62Registered outcomes23Posted comparisons0ConditionsInfertility, ObesityArmsNo pre-treatment, semaglutide
PMID 33567185PMID 36551163PMID 21806596PMID 26097395PMID 29221938PMID 29523133PMID 30763543PMID 30910544PMID 31260047PMID 33257906PMID 36635080PMID 37427372other papers from this trial
Open the trial in the graph
NCT05702905 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome: a Prospective, Randomized, Open, Controlled Study

TypeinterventionalSponsorPeking University First HospitalRan2023 to 2025Enrolled75ConditionsPCOS (Polycystic Ovary Syndrome), SemaglutideArmsMetformin Hydrochloride 500 MG, Semaglutide, 1.34 mg/mL, Semaglutide, 1.34 mg/mL and Metformin Hydrochloride 500 MG, calorie-restricted diet, physical exercise
3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 17 syntheses or guidelines pooled it, 173 citations in OpenAlex.

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  10. Adipose Tissue Dysfunction in Polycystic Ovary Syndrome.The Journal of clinical endocrinology and metabolism · 2023
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  15. Pharmacological and non-pharmacological strategies for obese women with subfertility.The Cochrane database of systematic reviews · 2021 · on this map
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Vesna SalamunDivision of Obstetrics and Gynecology, Department of Human Reproduction.
Mojca JensterleDepartment of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Andrej JanezDepartment of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Eda Vrtacnik BokalDivision of Obstetrics and Gynecology, Department of Human Reproduction.
Center for Human Reproduction · USLjubljana University Medical Centre · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveGlucagon-like peptide-1 (GLP-1) has been investigated in regulation of reproductive system in animal models. The potential impact of short-term preconception intervention with liraglutide on fertility potential in polycystic ovary syndrome (PCOS) has not been evaluated yet.

designA prospective randomized open-label study was conducted in 28 infertile obese PCOS patients (age: 31.07 ± 4.75, BMI: 36.7 ± 3.5 kg/m

methodsThe

resultsPatients in the MET group on average lost 7.0 ± 6.0 kg (

conclusionsPreconception intervention with low-dose liraglutide added to metformin is superior to metformin alone in increasing PRs per ET and cumulative PRs in infertile obese women with PCOS, despite comparable weight reduction in both groups. A potential impact of liraglutide on the reproductive system needs further exploration, in particular the GLP-1 impact on endometrial quality and receptivity.

Indexed as

Fertilization in VitroOvulation InductionPregnancy RateAdultDrug Therapy, CombinationFemaleHumansHypoglycemic AgentsInfertility, FemaleLiraglutideMetforminObesityPilot ProjectsPolycystic Ovary SyndromePregnancySperm Injections, IntracytoplasmicHypoglycemic AgentsLiraglutideMetformin

Identifiers

PMID29703793
OpenAlexW2799507126

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.